![cis trans 11 cis trans 11](https://ars.els-cdn.com/content/image/1-s2.0-S0021925820308279-gr1.jpg)
There was a significant negative correlation between mitogen-induced T lymphocyte activation and the proportions of both cis-9, trans-11 CLA and trans-10, cis-12 CLA in peripheral blood mononuclear cell lipids.
![cis trans 11 cis trans 11](https://s.yimg.com/uu/api/res/1.2/NHZTJYixYL0keVkdd4q.DA--~B/Zmk9c3RyaW07aD0yODg7dz01MTQ7YXBwaWQ9eXRhY2h5b24-/https://s.yimg.com/hd/cp-video-transcode/prod/2021-12/03/61a9e11b709d502188667165/61a9e11b709d502188667166_o_U_v2.jpg)
Results: Both CLA isomers decreased mitogen-induced T lymphocyte activation in a dose-dependent manner. This regimen was followed by a 6-wk washout and a crossover to the other isomer. Healthy men consumed 1, 2, and 4 capsules sequentially that contained 80% of either cis-9, trans-11 CLA or trans-10, cis-12 CLA for consecutive 8-wk periods. Objective: This study investigated the effects of supplementing the diet with 3 doses of highly enriched cis-9, trans-11 CLA (0.59, 1.19, and 2.38 g/d) or trans-10, cis-12 CLA (0.63, 1.26, and 2.52 g/d) on immune outcomes in healthy humans.ĭesign: The study had a randomized, double-blind, crossover design. Furthermore, the effects of individual isomers of CLA have not been adequately investigated. However, little information on the effects of CLA on immune function is available, especially in humans. Background: Animal studies have suggested that conjugated linoleic acid (CLA), a natural component of ruminant meat and dairy products, may confer beneficial effects on health.